PPIRE16391
Target Protein Information
| Protein_Name | Beta-2-microglobulin |
|---|---|
| Protein_Sequence | MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM |
| Organism_Source | Homo sapiens |
| Functional_Classification | MHC class1 |
| Cellular_Localization | Extracellular |
| Gene_Names | B2M |
| UniProt_ID | P61769 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | pep331 |
|---|---|
| Peptide_Sequence | CFETAWRQNEWC |
| Peptide_Length | 12 |
| Peptide_SMILES | C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<-->C12; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1572.73 |
|---|---|
| Aliphatic_Index | 8.33333 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 3.91667 |
| Charge_at_pH_7 | -1.12242 |
| Isoelectric_Point | 4.25807 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 21 |
| Number_of_Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 657.91000 |
| X_logP_energy | -5.18413 |
Interaction Information
| Affinity | KD=300 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Computational Evolution of Beta-2-Microglobulin Binding Peptides for Nanopatterned Surface Sensors |
| Release_Year | 2021 |
| PMID | 33467468 |
| DOI | 10.3390/ijms22020812 |