PPIRE16432

Target Protein Information
Protein_Name Bone morphogenetic protein 2
Protein_Sequence MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Organism_Source Homo sapiens
Functional_Classification TGF beta superfamily growth factor
Cellular_Localization Extracellular
Gene_Names BMP2
UniProt_ID P12643
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BMP binding peptide (BBP)
Peptide_Sequence FRIQETTCRRESEADPATC
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C8<-->C19; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2213.42
Aliphatic_Index 31.05263
Aromaticity 0.05263
Average_Rotatable_Bonds 3.78947
Charge_at_pH_7 -1.12020
Isoelectric_Point 4.58749
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1037.24000
X_logP_energy -13.92179
Interaction Information
Affinity KD=3 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title BMP binding peptide: a BMP-2 enhancing factor deduced from the sequence of native bovine bone morphogenetic protein/non-collagenous protein
Release_Year 2005
PMID 15607890
DOI 10.1016/j.orthres.2004.05.001