PPIRE16494

Target Protein Information
Protein_Name Transcriptional enhancer factor TEF-5
Protein_Sequence MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
Organism_Source Homo sapiens
Functional_Classification TEA domain family
Cellular_Localization Nucleus
Gene_Names TEAD3
UniProt_ID Q99594
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name YAP u-loop peptide
Peptide_Sequence MRLRKLPDSFFK
Peptide_Length 12
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification rhodamine
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1537.89
Aliphatic_Index 65.00000
Aromaticity 0.16667
Average_Rotatable_Bonds 4.33333
Charge_at_pH_7 2.99783
Isoelectric_Point 11.65089
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 608.00000
X_logP_energy -3.18046
Interaction Information
Affinity KD=38.4 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structure-based Derivation and Optimization of YAP-like Coactivator-derived Peptides to Selectively Target TEAD Family Transcription Factors by Hydrocarbon Stapling and Cyclization
Release_Year 2018
PMID 33283479
DOI 10.1111/CBDD.13813