PPIRE16516

Target Protein Information
Protein_Name Envelope glycoprotein D
Protein_Sequence MGGAAARLGAVILFVVIVGLHGVRGKYALADASLKMADPNRFRGKDLPVLDQLTDPPGVRRVYHIQAGLPDPFQPPSLPITVYYAVLERACRSVLLNAPSEAPQIVRGASEDVRKQPYNLTIAWFRMGGNCAIPITVMEYTECSYNKSLGACPIRTQPRWNYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEITQFILEHRAKGSCKYALPLRIPPSACLSPQAYQQGVTVDSIGMLPRFIPENQRTVAVYSLKIAGWHGPKAPYTSTLLPPELSETPNATQPELAPEDPEDSALLEDPVGTVAPQIPPNWHIPSIQDAATPYHPPATPNNMGLIAGAVGGSLLAALVICGIVYWMRRRTQKAPKRIRLPHIREDDQPSSHQPLFY
Organism_Source Human herpesvirus 1 (strain F)
Functional_Classification viral glycoproteins
Cellular_Localization Plasma membrane
Gene_Names gD
UniProt_ID Q05059
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LKNleADPNRFRGKDL
Peptide_Sequence LKXADPNRFRGKDL
Peptide_Length 14
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(=O)O
Chemical_Modification X2=norleucine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1586.81
Aliphatic_Index 62.85714
Aromaticity 0.07143
Average_Rotatable_Bonds 3.85714
Charge_at_pH_7 1.99828
Isoelectric_Point 10.77375
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 726.36000
X_logP_energy -7.56616
Interaction Information
Affinity EC50=18.9 pM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Synthesis solution structure analysis and antibody binding of cyclic epitope peptides from glycoprotein D of Herpes simplex virus type I
Release_Year 2003
PMID 14556904
DOI 10.1016/S0301-4622(03)00187-X