PPIRE16556

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
Organism_Source Homo sapiens
Functional_Classification IgG
Cellular_Localization Extracellular
Gene_Names IGHG1
UniProt_ID P01857
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Acetylated-HWRGWVA
Peptide_Sequence HWRGWVA
Peptide_Length 7
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 911.03
Aliphatic_Index 55.71429
Aromaticity 0.28571
Average_Rotatable_Bonds 3.42857
Charge_at_pH_7 1.08889
Isoelectric_Point 10.55176
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 360.08000
X_logP_energy -0.70853
Interaction Information
Affinity KD=10 uM
Affinity_Assay quartz crystal microgravimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Specific Binding of Immunoglobulin G with Bioactive Short Peptides Supported on Antifouling Copolymer Layers for Detection in Quartz Crystal Microgravimetry and Surface Plasmon Resonance
Release_Year 2012
PMID 23231671
DOI 10.1021/ac302874s