PPIRE16558

Target Protein Information
Protein_Name Complement C1q subcomponent subunit A
Protein_Sequence MEGPRGWLVLCVLAISLASMVTEDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQGEPGPSGNPGKVGYPGPSGPLGARGIPGIKGTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSA
Organism_Source Homo sapiens
Functional_Classification complement components
Cellular_Localization Extracellular
Gene_Names C1QA
UniProt_ID P02745
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name d8-22
Peptide_Sequence PAICQRAEIEACILL
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1642.99
Aliphatic_Index 150.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.60000
Charge_at_pH_7 -1.12242
Isoelectric_Point 4.25807
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 636.32000
X_logP_energy -3.98163
Interaction Information
Affinity KD=5.43 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility
Release_Year 2012
PMID 22906481
DOI 10.1016/j.molimm.2012.07.012