PPIRE16567

Target Protein Information
Protein_Name Ig gamma-2 chain C region
Protein_Sequence SARTTAPSVFPLAASCVDTSGSMMTLGCLVKGYFPEPVTVKWNSGALTSGVHTFPAVLQSGLYSLTSMVTVPSSQKATCNVAHPASSTKVDKTVEPIRTPZPBPCTCPKCPPPENLGGPSVFIFPPKPKDTLMISLTPRVTCVVVDVSQDEPEVQFTWFVDNKPVGNAETKPRVEQYNTTFRVESVLPIQHQDWLRGKEFKCKVYNKALPAPIEKTISKTKGAPRMPDVYTLPPSRDELSKSKVSVTCLIINFFPADIHVEWASNRVPVSEKEYKNTPPIEDADGSYFLYSKLTVDKSAWDQGTVYTCSVMHEALHNHVTQKAISRSPG
Organism_Source Cavia porcellus
Functional_Classification immunoglobulins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P01862
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Sulf.(Nle15)-HG-17
Peptide_Sequence XGPWLEEEEAYGWXDF
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification X1=pyroglutamate; X15=norleucine; Y12=sulfotyrosine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1841.91
Aliphatic_Index 30.62500
Aromaticity 0.25000
Average_Rotatable_Bonds 3.37500
Charge_at_pH_7 -4.99532
Isoelectric_Point 3.25717
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 729.34000
X_logP_energy -3.65900
Interaction Information
Affinity IC50=3 pM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Induction and Detection of Anti-Peptide Antibody Specificity Is Critically Affected by the Mode of Hapten Presentation
Release_Year 1992
PMID 1381185
DOI 10.1515/bchm3.1992.373.1.315