PPIRE16593

Target Protein Information
Protein_Name L-lactate dehydrogenase B chain
Protein_Sequence MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
Organism_Source Homo sapiens
Functional_Classification dehydrogenases
Cellular_Localization Cytoplasm
Gene_Names LDHB
UniProt_ID P07195
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LB19
Peptide_Sequence ATLKEKLIAPVAEEEATVP
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2009.33
Aliphatic_Index 113.15789
Aromaticity 0.00000
Average_Rotatable_Bonds 3.42105
Charge_at_pH_7 -1.99551
Isoelectric_Point 4.18923
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 811.24000
X_logP_energy -5.85420
Interaction Information
Affinity KD=1.78 mM
Affinity_Assay Microscale Thermophoresis
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides
Release_Year 2020
PMID 32250117
DOI 10.1021/acs.jmedchem.9b01955