PPIRE16722
Target Protein Information
| Protein_Name | Protein c-Fos |
|---|---|
| Protein_Sequence | MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL |
| Organism_Source | Homo sapiens |
| Functional_Classification | bZIP transcription factor |
| Cellular_Localization | Nucleus |
| Gene_Names | FOS |
| UniProt_ID | P01100 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | JunW |
|---|---|
| Peptide_Sequence | ASAAELEERVKTLKAEIYELQSEANMLREQIAQLGAP |
| Peptide_Length | 37 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 4101.64 |
|---|---|
| Aliphatic_Index | 100.54054 |
| Aromaticity | 0.02703 |
| Average_Rotatable_Bonds | 3.86486 |
| Charge_at_pH_7 | -2.99104 |
| Isoelectric_Point | 4.26993 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 58 |
| Number_of_Hydrogen_Bond_Donors | 60 |
| Topological_Polar_Surface_Area | 1792.35000 |
| X_logP_energy | -17.31646 |
Interaction Information
| Affinity | KD=0.79 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Thermodynamic analysis of Junos coiled coil peptide antagonists Inferences for optimization of enthalpic binding forces |
| Release_Year | 2011 |
| PMID | 21199371 |
| DOI | 10.1111/j.1742-4658.2010.07988.x |