PPIRE16756

Target Protein Information
Protein_Name Beta-2 adrenergic receptor
Protein_Sequence MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names ADRB2
UniProt_ID P07550
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P3
Peptide_Sequence EDTAVYYCNANWDLLSD
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1992.10
Aliphatic_Index 74.70588
Aromaticity 0.17647
Average_Rotatable_Bonds 3.52941
Charge_at_pH_7 -4.06258
Isoelectric_Point 3.26047
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 861.01000
X_logP_energy -8.09370
Interaction Information
Affinity KD=3.57 uM
Affinity_Assay Microscale Thermophoresis
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Computational design and characterization of nanobody-derived peptides that stabilize the active conformation of the u2-adrenergic receptor (u2-AR)
Release_Year 2019
PMID 31719570
DOI 10.1038/s41598-019-52934-8