PPIRE16766
Target Protein Information
| Protein_Name | Speract receptor |
|---|---|
| Protein_Sequence | MAHARHLFLFMVAFTITMVIARLDFNPTIINEDRGRTKIHVGLLAEWTTADGDQGTLGFPALGALPLAISLANQDSNILNGFDVQFEWVDTHCDINIGMHAVSDWWKRGFVGVIGPGCGCTYEGRLASALNIPMIDYVCDENPVSDKSIYPTFLRTIPPSIQVVEAIILTLQRYELDQVSVVVENITKYRNIFNTMKDKFDERDYEILHEEYYAGFDPWDYEMDDPFSEIIQRTKETTRIYVFFGDASDLRQFAMTALDEGILDSGDYVILGAVVDLEVRDSQDYHSLDYILDTSEYLNQINPDYARLFKNREYTRSDNDRALEALKSVIIVTGAPVLKTRNWDRFSTFVIDNALDAPFNGELELRAEIDFASVYMFDATMQLLEALDRTHAAGGDIYDGEEVVSTLLNSTYRSKTDTFYQFDENGDGVKPYVLLHLIPIPKGDGGATKDSLGMYPIGTFNRENGQWGFEEALDEDANVLKPVWHNRDEPPLDMPPCGFHGELCTNWALYLGASIPTFLIIFGGLIGFFIYRKRAYEAALDSLVWKVDWSEVQTKATDTNSQGFSMKNMVMSAISVISNAEKQQIFATIGTYRGTVCALHAVHKNHIDLTRAVRTELKIMRDMRHDNICPFIGACIDRPHISILMHYCAKGSLQDILENDDIKLDSMFLSSLIADLVKGIVYLHSSEIKSHGHLKSSNCVVDNRWVLQITDYGLNEFKKGQKQDVDLGDHAKLARQLWTSPEHLRQEGSMPTAGSPQGDIYSFAIILTELYSRQEPFHENEMDLADIIGRVKSGEVPPYRPILNAVNAAAPDCVLSAIRACWPEDPADRPNIMAVRTMLAPLQKGLKPNILDNMIAIMERYTNNLEELVDERTQELQKEKTKTEQLLHRMLPPSIASQLIKGIAVLPETFEMVSIFFSDIVGFTALSAASTPIQVVNLLNDLYTLFDAIISNYDVYKVETIGDAYMLVSGLPLRNGDRHAGQIASTAHHLLESVKGFIVPHKPEVFLKLRIGIHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGLALRIHVSPWCKQVLDKLGGYELEDRGLVPMNGKGEIHTFWLLGQDPSYKITKVKPPPQKLTQEAIEIAANRVIPDDV |
| Organism_Source | Strongylocentrotus purpuratus |
| Functional_Classification | chemoreceptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | None |
| UniProt_ID | P16065 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | speract |
|---|---|
| Peptide_Sequence | GFDLNGGGVG |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@H](C(=O)NCC(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 891.94 |
|---|---|
| Aliphatic_Index | 68.00000 |
| Aromaticity | 0.10000 |
| Average_Rotatable_Bonds | 2.80000 |
| Charge_at_pH_7 | -1.00157 |
| Isoelectric_Point | 3.74999 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 405.61000 |
| X_logP_energy | -5.78660 |
Interaction Information
| Affinity | IC50=8 nM |
|---|---|
| Affinity_Assay | Competition binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | FRET analysis using sperm-activating peptides tagged with fluorescent proteins reveals that ligand-binding sites exist as clusters |
| Release_Year | 2016 |
| PMID | 26889001 |
| DOI | 10.1242/jeb.127662 |