PPIRE16796

Target Protein Information
Protein_Name Aliphatic amidase expression-regulating protein
Protein_Sequence MGSHQERPLIGLLFSETGVTADIERSQRYGALLAVEQLNREGGVGGRPIETLSQDPGGDPDRYRLCAEDFIRNRGVRFLVGCYMSHTRKAVMPVVERADALLCYPTPYEGFEYSPNIVYGGPAPNQNSAPLAAYLIRHYGERVVFIGSDYIYPRESNHVMRHLYRQHGGTVLEEIYIPLYPSDDDVQRAVERIYQARADVVFSTVVGTGTAELYRAIARRYGDGRRPPIASLTTSEAEVAKMESDVAEGQVVVAPYFSSIDTAASRAFVQACHGFFPENATITAWAEAAYWQTLLLGRAAQAAGSWRVEDVQRHLYDICIDAPQGPVRVERQNNHSRLSSRIAEIDARGVFQVRWQSPEPIRPDPYVVVHNLDDWSASMGGGALP
Organism_Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Functional_Classification natriuretic peptide receptorike
Cellular_Localization Cytoplasm
Gene_Names amiC
UniProt_ID P27017
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CNP
Peptide_Sequence NPGLPLGLGRGSCGLADRSAKS
Peptide_Length 22
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C6<-->C22; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2126.42
Aliphatic_Index 80.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.13636
Charge_at_pH_7 1.93615
Isoelectric_Point 9.82825
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 947.74000
X_logP_energy -14.11496
Interaction Information
Affinity KD=2 uM
Affinity_Assay Microscale Thermophoresis
PDB_ID 1PEA
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Pseudomonas aeruginosa expresses a functional human natriuretic peptide receptor ortholog: involvement in biofilm formation
Release_Year 2015
PMID 26307165
DOI 10.1128/mBio.01033-15