PPIRE16802
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MEIGETVEFIRHSKNISIKQVCGDYLTRQTCYRFIKNNLDISSKKLLYILDNLNVNVDEFLFISNNFKQYKEFIDMDTAKHYFECRNIEGLNHILDSYKDSKSTKEKNLFALVKVLLATLTEEDCLTERTYLSNYLINIETWSHYETVLFNNCMFIFESCFIEMVFSKVILNLDKYNTLRYYGNESIRMFVNMLILFIQRQEYDKASEILAKIEDYQLNDDCLYERCCVSFFDGIIGLINGKEGAEQKCVQILEIFQLLNCKTIHHMFQTYLEAIKHKLS |
| Organism_Source | Streptococcus pyogenes |
| Functional_Classification | Rgg family transcription factors |
| Cellular_Localization | Cytoplasm |
| Gene_Names | rgg |
| UniProt_ID | D3KVD8 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SHP3-C8 |
|---|---|
| Peptide_Sequence | DIIIIVGG |
| Peptide_Length | 8 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | FITC |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 798.98 |
|---|---|
| Aliphatic_Index | 231.25000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | -1.00157 |
| Isoelectric_Point | 3.74999 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 10 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 304.32000 |
| X_logP_energy | -0.63020 |
Interaction Information
| Affinity | KD=1.7 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Multiple Length Peptide-Pheromone Variants Produced by Streptococcus pyogenes Directly Bind Rgg Proteins to Confer Transcriptional Regulation |
| Release_Year | 2014 |
| PMID | 24958729 |
| DOI | 10.1074/jbc.M114.583989 |