PPIRE16825

Target Protein Information
Protein_Name Cellular tumor antigen p53
Protein_Sequence MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Organism_Source Homo sapiens
Functional_Classification sequence specific DNA binding transcription factor
Cellular_Localization Nucleus
Gene_Names TP53
UniProt_ID P04637
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name S100A4(615)
Peptide_Sequence NLDSNRDNEVDFQEY
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1857.86
Aliphatic_Index 45.33333
Aromaticity 0.13333
Average_Rotatable_Bonds 4.13333
Charge_at_pH_7 -3.99798
Isoelectric_Point 3.60605
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 931.94000
X_logP_energy -11.62043
Interaction Information
Affinity KD=98 uM
Affinity_Assay fluorescence anisotropy
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Specific Recognition of p53 Tetramers by Peptides Derived from p53 Interacting Proteins
Release_Year 2012
PMID 22693587
DOI 10.1371/journal.pone.0038060