PPIRE16847
Target Protein Information
| Protein_Name | Immunoglobulin kappa constant |
|---|---|
| Protein_Sequence | RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Organism_Source | Homo sapiens |
| Functional_Classification | Fab fragments |
| Cellular_Localization | Extracellular |
| Gene_Names | IGKC |
| UniProt_ID | P01834 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | C7 |
|---|---|
| Peptide_Sequence | HQNHHSTFWEIY |
| Peptide_Length | 12 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1598.70 |
|---|---|
| Aliphatic_Index | 32.50000 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 3.91667 |
| Charge_at_pH_7 | -0.72836 |
| Isoelectric_Point | 6.79248 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 22 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 669.42000 |
| X_logP_energy | -5.03160 |
Interaction Information
| Affinity | KD=100 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Development of phage biopanning strategies to identify affinity peptide ligands for kappa light chain Fab fragments |
| Release_Year | 2019 |
| PMID | 31301216 |
| DOI | 10.1002/btpr.2884 |