PPIRE16891

Target Protein Information
Protein_Name Gamma-synuclein
Protein_Sequence MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD
Organism_Source Homo sapiens
Functional_Classification intrinsically disordered proteins
Cellular_Localization Cytoplasm
Gene_Names SNCG
UniProt_ID O76070
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ANK peptide
Peptide_Sequence KGNSALHVASQHGHLGCIQTLVRYGANVTMQNHG
Peptide_Length 34
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)O)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3600.05
Aliphatic_Index 80.29412
Aromaticity 0.02941
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 2.29850
Isoelectric_Point 9.45282
Number_of_Hydrogen_Bond_Acceptors 54
Number_of_Hydrogen_Bond_Donors 55
Topological_Polar_Surface_Area 1585.95000
X_logP_energy -21.17863
Interaction Information
Affinity KD=70 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Synuclein-缂傚倸鍊风粈浣规櫠娴犲绠栫紒璺虹eting Peptide Inhibitor that Enhances Sensitivity of Breast Cancer Cells to Antimicrotubule Drugs
Release_Year 2007
PMID 17234772
DOI 10.1158/0008-5472.CAN-06-1820