PPIRE16896

Target Protein Information
Protein_Name Bcl-2-like protein 10
Protein_Sequence MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
Organism_Source Homo sapiens
Functional_Classification Bcl 2 family proteins
Cellular_Localization Mitochondria
Gene_Names BCL2L10
UniProt_ID Q9HD36
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FITC-TR3-r8
Peptide_Sequence FSRSLHSLLGXrrrrrrrr
Peptide_Length 19
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification X11=N-aminocaproic acid; r12=D-Arginine; r13=D-Arginine; r14=D-Arginine; r15=D-Arginine; r16=D-Arginine; r17=D-Arginine; r18=D-Arginine; r19=D-Arginine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2422.84
Aliphatic_Index 61.57895
Aromaticity 0.05263
Average_Rotatable_Bonds 4.52632
Charge_at_pH_7 9.08886
Isoelectric_Point 13.40310
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 51
Topological_Polar_Surface_Area 1233.59000
X_logP_energy -15.91937
Interaction Information
Affinity KD=20 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A TR3/Nur77 Peptide-Based High-Throughput Fluorescence Polarization Screen for Small Molecule Bcl-B Inhibitors
Release_Year 2008
PMID 18626112
DOI 10.1177/1087057108320918