PPIRE16906

Target Protein Information
Protein_Name Potassium voltage-gated channel subfamily A member 3
Protein_Sequence MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
Organism_Source Homo sapiens
Functional_Classification voltage gated potassium channels
Cellular_Localization Plasma membrane
Gene_Names KCNA3
UniProt_ID P22001
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ts11
Peptide_Sequence KPKCGLCRYRCCSGGCSSGKCVNGACDCS
Peptide_Length 29
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C4<-->C12; disulfide bond; C7<-->C28; disulfide bond; C11<-->C21; disulfide bond; C16<-->C26; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2946.45
Aliphatic_Index 26.89655
Aromaticity 0.03448
Average_Rotatable_Bonds 3.34483
Charge_at_pH_7 3.50089
Isoelectric_Point 8.40775
Number_of_Hydrogen_Bond_Acceptors 50
Number_of_Hydrogen_Bond_Donors 53
Topological_Polar_Surface_Area 1252.73000
X_logP_energy -21.02256
Interaction Information
Affinity IC50=17.1 uM
Affinity_Assay Patch-clamp electrophysiology
PDB_ID 2MSF
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins
Release_Year 2016
PMID 27706049
DOI 10.3390/toxins8100288