PPIRE16909

Target Protein Information
Protein_Name Sex peptide receptor
Protein_Sequence MDNYTDVLYQYRLAPSASPEMEMELADPRQMVRGFHLPTNESQLEIPDYGNESLDYPNYQQMVGGPCRMEDNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSKKSMATPTNFVLMGMAICDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLAYSIFNEIMPAMCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVCHLETSMWVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNTNETVL
Organism_Source Drosophila melanogaster
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SPR
UniProt_ID Q8SWR3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MIP3
Peptide_Sequence EPTWNNLKGMWa
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1446.64
Aliphatic_Index 40.83333
Aromaticity 0.16667
Average_Rotatable_Bonds 3.58333
Charge_at_pH_7 -0.00054
Isoelectric_Point 6.40880
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 575.94000
X_logP_energy -3.73880
Interaction Information
Affinity EC50=24.9 nM
Affinity_Assay aequorin-based calcium mobilization assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Sex peptides and MIPs can activate the same G protein-coupled receptor
Release_Year 2013
PMID 23453963
DOI 10.1016/j.ygcen.2013.02.014