PPIRE16911

Target Protein Information
Protein_Name Sex peptide receptor
Protein_Sequence MDNYTDVLYQYRLAPSASPEMEMELADPRQMVRGFHLPTNESQLEIPDYGNESLDYPNYQQMVGGPCRMEDNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSKKSMATPTNFVLMGMAICDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLAYSIFNEIMPAMCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVCHLETSMWVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNTNETVL
Organism_Source Drosophila melanogaster
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SPR
UniProt_ID Q8SWR3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MIP5
Peptide_Sequence pQAQGWNKFRGAWa
Peptide_Length 14
Peptide_SMILES C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1)C(=O)O
Chemical_Modification pQ1=pyroglutamic acid
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification pyroglutamic acid
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1616.80
Aliphatic_Index 21.42857
Aromaticity 0.21429
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.99769
Isoelectric_Point 11.65178
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 676.40000
X_logP_energy -6.06273
Interaction Information
Affinity EC50=10.8 nM
Affinity_Assay aequorin-based calcium mobilization assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Sex peptides and MIPs can activate the same G protein-coupled receptor
Release_Year 2013
PMID 23453963
DOI 10.1016/j.ygcen.2013.02.014