PPIRE16914

Target Protein Information
Protein_Name Sex peptide receptor
Protein_Sequence MDNYTDVLYQYRLAPSASPEMEMELADPRQMVRGFHLPTNESQLEIPDYGNESLDYPNYQQMVGGPCRMEDNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSKKSMATPTNFVLMGMAICDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLAYSIFNEIMPAMCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVCHLETSMWVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNTNETVL
Organism_Source Drosophila melanogaster
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SPR
UniProt_ID Q8SWR3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Trp2Ala
Peptide_Sequence DQWQKLHGGAa
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1210.31
Aliphatic_Index 53.63636
Aromaticity 0.09091
Average_Rotatable_Bonds 3.54545
Charge_at_pH_7 0.08904
Isoelectric_Point 7.54935
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 548.29000
X_logP_energy -5.58050
Interaction Information
Affinity EC50=100 nM
Affinity_Assay aequorin-based calcium mobilization assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Sex peptides and MIPs can activate the same G protein-coupled receptor
Release_Year 2013
PMID 23453963
DOI 10.1016/j.ygcen.2013.02.014