PPIRE16916

Target Protein Information
Protein_Name Casein kinase II subunit beta
Protein_Sequence MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
Organism_Source Homo sapiens
Functional_Classification protein kinases
Cellular_Localization Cytoplasm
Gene_Names CSNK2B
UniProt_ID P67870
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P1
Peptide_Sequence GKMNGVLPLAWPSLYLRLP
Peptide_Length 19
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2125.60
Aliphatic_Index 123.15789
Aromaticity 0.10526
Average_Rotatable_Bonds 3.31579
Charge_at_pH_7 1.99684
Isoelectric_Point 10.45492
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 748.01000
X_logP_energy -2.50213
Interaction Information
Affinity KD=0.4 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2
Release_Year 2006
PMID 16751801
DOI 10.1038/sj.onc.1209722