PPIRE16938

Target Protein Information
Protein_Name Protein PA-X
Protein_Sequence MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKDLKSQGQCAGLPTKVSRRTSPALRILEPMWMDSNRTATLRASFLKCPKK
Organism_Source Influenza A virus (strain A/Northern Territory/60/1968 H3N2)
Functional_Classification polymerases
Cellular_Localization Nucleus
Gene_Names PA
UniProt_ID P0DJT7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PB11-15T6A
Peptide_Sequence MDVNPALLFLKVPAQ
Peptide_Length 15
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1656.02
Aliphatic_Index 130.00000
Aromaticity 0.06667
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 -0.00186
Isoelectric_Point 6.33737
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 602.64000
X_logP_energy -2.57160
Interaction Information
Affinity IC50=1835.7 nM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase
Release_Year 2011
PMID 21135188
DOI 10.1128/AAC.01419-10