PPIRE16948

Target Protein Information
Protein_Name Protein PA-X
Protein_Sequence MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKDLKSQGQCAGLPTKVSRRTSPALRILEPMWMDSNRTATLRASFLKCPKK
Organism_Source Influenza A virus (strain A/Northern Territory/60/1968 H3N2)
Functional_Classification polymerases
Cellular_Localization Nucleus
Gene_Names PA
UniProt_ID P0DJT7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PB11-15T6Y
Peptide_Sequence MDVNPYLLFLKVPAQ
Peptide_Length 15
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1748.11
Aliphatic_Index 123.33333
Aromaticity 0.13333
Average_Rotatable_Bonds 3.53333
Charge_at_pH_7 -0.00271
Isoelectric_Point 6.33059
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 622.87000
X_logP_energy -1.64320
Interaction Information
Affinity IC50=21.64 nM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase
Release_Year 2011
PMID 21135188
DOI 10.1128/AAC.01419-10