PPIRE17017
Target Protein Information
| Protein_Name | Antitoxin epsilon |
|---|---|
| Protein_Sequence | MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA |
| Organism_Source | Streptococcus pyogenes |
| Functional_Classification | toxin antitoxin antitoxin |
| Cellular_Localization | Cytoplasm |
| Gene_Names | None |
| UniProt_ID | Q57231 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Fluo-IIc |
|---|---|
| Peptide_Sequence | GSGDTSLRSAEFEETQ |
| Peptide_Length | 16 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | fluoresceinyl-carboxy |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1713.73 |
|---|---|
| Aliphatic_Index | 30.62500 |
| Aromaticity | 0.06250 |
| Average_Rotatable_Bonds | 3.62500 |
| Charge_at_pH_7 | -2.99625 |
| Isoelectric_Point | 3.77824 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 28 |
| Number_of_Hydrogen_Bond_Donors | 30 |
| Topological_Polar_Surface_Area | 855.16000 |
| X_logP_energy | -13.42183 |
Interaction Information
| Affinity | KD=134 nM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 1GVN |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Mapping Proteinrotein Interactions of the Resistance-Related Bacterial Zeta Toxinpsilon Antitoxin Complex (-2-2) with High Af-鍌氬€烽悞锕傚磿閹惰棄桅婵せ鍋撻柟宕囧枛閹偛鈻旈崕 Peptide Ligands Using Fluorescence Polarization |
| Release_Year | 2016 |
| PMID | 27438853 |
| DOI | 10.3390/toxins8070222 |