PPIRE17027

Target Protein Information
Protein_Name ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Protein_Sequence MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQRAGLIIPLFLVLASRTQL
Organism_Source Homo sapiens
Functional_Classification GPI anchored membrane receptor
Cellular_Localization Plasma membrane
Gene_Names BST1
UniProt_ID Q10588
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H01A
Peptide_Sequence ASQISGKYQRYLKDA
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1727.94
Aliphatic_Index 65.33333
Aromaticity 0.13333
Average_Rotatable_Bonds 3.93333
Charge_at_pH_7 1.99614
Isoelectric_Point 9.92854
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 789.06000
X_logP_energy -8.64293
Interaction Information
Affinity KD=1973 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Weak interaction between inhibition peptides and a soluble receptor of fusion protein in the liquid phase
Release_Year 2006
PMID 16966807
DOI 10.2116/analsci.22.1185