PPIRE17088

Target Protein Information
Protein_Name Ribonuclease pancreatic
Protein_Sequence MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV
Organism_Source Bos taurus
Functional_Classification endoribonucleases
Cellular_Localization Extracellular
Gene_Names RNASE1
UniProt_ID P61823
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name polar bias
Peptide_Sequence KETEEAGFEQRQHMDSSSTA
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2268.35
Aliphatic_Index 10.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.95000
Charge_at_pH_7 -2.90386
Isoelectric_Point 4.29740
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1106.65000
X_logP_energy -16.16203
Interaction Information
Affinity KD=10000 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title High Affinity RNase S-Peptide Variants Obtained by Phage Display Have a Novel ot-Spotof Binding Energy
Release_Year 2001
PMID 11695896
DOI 10.1021/bi011703b