PPIRE17127

Target Protein Information
Protein_Name None
Protein_Sequence MNIRNKIENSKTLLFTSLVAVALLGATQPVSAETYTSRNFDWPEDDWSGDGLSKYDRSGVGLSQYGWSKYGWSSDKEEWPEDWPEDDWSSDKKDETEDKTRPPYGEALGTGYEKRDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWRGPGHIPKPENEQSPNPSHIPEPPQIEWPQWNGFDGLSSGPSDWGQSEDTPRFPSEPRVTEKPQHTPQKNPQESDFDRGFSAGLKAKNSGRGIDFEGFQYGGWSDEYKKGYMQAFGTPYTPSAT
Organism_Source Streptococcus pyogenes
Functional_Classification Bacterial toxins immune evasion factors
Cellular_Localization Extracellular
Gene_Names sic
UniProt_ID F2WZ73
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name hBD-3
Peptide_Sequence GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRGW
Peptide_Length 45
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 5148.11
Aliphatic_Index 67.11111
Aromaticity 0.06667
Average_Rotatable_Bonds 3.91111
Charge_at_pH_7 8.62678
Isoelectric_Point 10.26205
Number_of_Hydrogen_Bond_Acceptors 74
Number_of_Hydrogen_Bond_Donors 88
Topological_Polar_Surface_Area 2213.35000
X_logP_energy -24.92691
Interaction Information
Affinity KD=35.19 mM
Affinity_Assay Farr precipitation assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides components of mucosal innate immunity: a comparison of their activities
Release_Year 2007
PMID 17303463
DOI 10.1016/j.micinf.2006.12.006