PPIRE17227

Target Protein Information
Protein_Name Protein B14 homolog
Protein_Sequence MSSSNYVYRNNFSDDDDITTAISDYLFWSSLAFSSREVAGNVFLVFESFKKDASLVFGNDLTAFVKNMFLDSKIGFEQSKIMINSMLKKENHIRESCAVIGILARAAEYWGGESSPTCSSMKVLVLLRDLVSDNDISLVKSALIIRLKRLNEKSIHLQV
Organism_Source Sheeppox virus (strain InS-1)
Functional_Classification Viral modulators of host response kelch like virulence factors
Cellular_Localization Mitochondria
Gene_Names None
UniProt_ID P18387
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Bok_BH3
Peptide_Sequence VPGRLAEVCAVLLRLGDELEMIRPSV
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2836.40
Aliphatic_Index 142.30769
Aromaticity 0.00000
Average_Rotatable_Bonds 3.57692
Charge_at_pH_7 -1.05823
Isoelectric_Point 4.58756
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1128.37000
X_logP_energy -7.73199
Interaction Information
Affinity KD=7.58 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Crystal structures of the sheeppoxvirus encoded inhibitor of apoptosis SPPV14 bound to Hrk and Bax BH3 peptides
Release_Year 2020
PMID 32390192
DOI 10.1002/1873-3468.13807