PPIRE17229

Target Protein Information
Protein_Name Protein B14 homolog
Protein_Sequence MSSSNYVYRNNFSDDDDITTAISDYLFWSSLAFSSREVAGNVFLVFESFKKDASLVFGNDLTAFVKNMFLDSKIGFEQSKIMINSMLKKENHIRESCAVIGILARAAEYWGGESSPTCSSMKVLVLLRDLVSDNDISLVKSALIIRLKRLNEKSIHLQV
Organism_Source Sheeppox virus (strain InS-1)
Functional_Classification Viral modulators of host response kelch like virulence factors
Cellular_Localization Mitochondria
Gene_Names None
UniProt_ID P18387
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Bax_BH3 (residues 52-74)
Peptide_Sequence DTFSDLSLGELDRIQRGLAGDL
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2391.62
Aliphatic_Index 110.90909
Aromaticity 0.04545
Average_Rotatable_Bonds 3.72727
Charge_at_pH_7 -2.99846
Isoelectric_Point 3.88423
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1088.50000
X_logP_energy -12.06646
Interaction Information
Affinity KD=0.026 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID 6XY6
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Crystal structures of the sheeppoxvirus encoded inhibitor of apoptosis SPPV14 bound to Hrk and Bax BH3 peptides
Release_Year 2020
PMID 32390192
DOI 10.1002/1873-3468.13807