PPIRE17250
Target Protein Information
| Protein_Name | Growth factor receptor-bound protein 7 |
|---|---|
| Protein_Sequence | MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL |
| Organism_Source | Homo sapiens |
| Functional_Classification | SH2 domain containing proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | GRB7 |
| UniProt_ID | Q14451 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | G7-M2 |
|---|---|
| Peptide_Sequence | CDNAXNATGAC |
| Peptide_Length | 11 |
| Peptide_SMILES | C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | X5=carboxyphenylalanine |
| Cyclization_Method | main chainide chain cyclization; N1<-->C11; thioether bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 996.03 |
|---|---|
| Aliphatic_Index | 27.27273 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.72727 |
| Charge_at_pH_7 | -1.12552 |
| Isoelectric_Point | 3.74996 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 498.03000 |
| X_logP_energy | -9.96530 |
Interaction Information
| Affinity | KD=2.1 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity |
| Release_Year | 2019 |
| PMID | 31627265 |
| DOI | 10.3390/molecules24203739 |