PPIRE17328
Target Protein Information
| Protein_Name | Fibrinogen gamma chain |
|---|---|
| Protein_Sequence | MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTIGEGQQHHLGGAKQVRPEHPAETEYDSLYPEDDL |
| Organism_Source | Homo sapiens |
| Functional_Classification | fibrillar proteins |
| Cellular_Localization | Extracellular |
| Gene_Names | FGG |
| UniProt_ID | P02679 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H-LysGluLys-NH2 |
|---|---|
| Peptide_Sequence | KEK |
| Peptide_Length | 3 |
| Peptide_SMILES | NCCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 403.48 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 5.33333 |
| Charge_at_pH_7 | 0.99917 |
| Isoelectric_Point | 9.53730 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 7 |
| Number_of_Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 210.86000 |
| X_logP_energy | -1.50930 |
Interaction Information
| Affinity | KD=15 mM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | 1FZC |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Computational modeling and surface plasmon resonance analyses in the assessment of peptide ligands interacting with fibrin g(31224) epitope |
| Release_Year | 2008 |
| PMID | 19058882 |
| DOI | 10.1016/j.ejmech.2008.10.029 |