PPIRE17334
Target Protein Information
| Protein_Name | Fibrinogen gamma chain |
|---|---|
| Protein_Sequence | MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTIGEGQQHHLGGAKQVRPEHPAETEYDSLYPEDDL |
| Organism_Source | Homo sapiens |
| Functional_Classification | fibrillar proteins |
| Cellular_Localization | Extracellular |
| Gene_Names | FGG |
| UniProt_ID | P02679 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ac-ArgAspLysAspArg-OH |
|---|---|
| Peptide_Sequence | RDKDR |
| Peptide_Length | 5 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 688.74 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 5.00000 |
| Charge_at_pH_7 | 0.99858 |
| Isoelectric_Point | 9.69016 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 404.14000 |
| X_logP_energy | -5.05756 |
Interaction Information
| Affinity | KD=16.8 mM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | 1FZC |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Computational modeling and surface plasmon resonance analyses in the assessment of peptide ligands interacting with fibrin g(31224) epitope |
| Release_Year | 2008 |
| PMID | 19058882 |
| DOI | 10.1016/j.ejmech.2008.10.029 |