PPIRE17337

Target Protein Information
Protein_Name Falcipain-2b
Protein_Sequence MDYHMDYIPNEVISHQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFILFYFTPNFRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDNKMKDINKNNNNNTSSDFKGLSLFKENKPSNNFIHNENYFINVFDHKFLMNNVEHINQFYTFIKTNNKQYNSPNEMKERFQVFLQNAHKVKMHNNNKKSLYKKELNRFADLTYHEFKSKYLTLRSSKPLKNSKYLLDQINYDAVIKKYKGNENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICTDDDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISIAVSDDFPFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
Organism_Source Plasmodium falciparum (isolate 3D7)
Functional_Classification cysteine proteases
Cellular_Localization Lysosome
Gene_Names FP2B
UniProt_ID Q8I6U5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AnkP
Peptide_Sequence NVSARFWLSD
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(N)=O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1194.31
Aliphatic_Index 78.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.60000
Charge_at_pH_7 -0.00157
Isoelectric_Point 6.33872
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 523.76000
X_logP_energy -4.95183
Interaction Information
Affinity Ki=2 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Ankyrin Peptide Blocks Falcipain-2-mediated Malaria Parasite Release from Red Blood Cells
Release_Year 2003
PMID 12775709
DOI 10.1074/jbc.M305132200