PPIRE17349
Target Protein Information
| Protein_Name | Interleukin-6 receptor subunit alpha |
|---|---|
| Protein_Sequence | MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR |
| Organism_Source | Homo sapiens |
| Functional_Classification | cytokine receptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | IL6R |
| UniProt_ID | P08887 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Cys4A |
|---|---|
| Peptide_Sequence | MGCHSTFVGTLCFVALGEYPTLCYDTFVDRCA |
| Peptide_Length | 32 |
| Peptide_SMILES | CSCC[C@H](N)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | Multi-point cyclization; C3<-->C31; disulfide bond; C12<-->C23; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3521.07 |
|---|---|
| Aliphatic_Index | 70.00000 |
| Aromaticity | 0.15625 |
| Average_Rotatable_Bonds | 3.31250 |
| Charge_at_pH_7 | -2.15804 |
| Isoelectric_Point | 4.36590 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 50 |
| Number_of_Hydrogen_Bond_Donors | 50 |
| Topological_Polar_Surface_Area | 1300.72000 |
| X_logP_energy | -11.37063 |
Interaction Information
| Affinity | IC50=0.236 uM |
|---|---|
| Affinity_Assay | cell proliferation assay |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Antagonistic effect of disul-鍌氬€烽悞锕傚磿閹惰棄桅婵℃濞-rich peptide aptamers selected by cDNA display on interleukin-6-dependent cell proliferation |
| Release_Year | 2012 |
| PMID | 22503683 |
| DOI | 10.1016/j.bbrc.2012.03.130 |