PPIRE17356

Target Protein Information
Protein_Name Insulin-like growth factor-binding protein 1
Protein_Sequence MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
Organism_Source Homo sapiens
Functional_Classification IGF binding proteins
Cellular_Localization Extracellular
Gene_Names IGFBP1
UniProt_ID P08833
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name bp1-02
Peptide_Sequence SEVGCRAGPLQWLCEKYFG
Peptide_Length 19
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method Side chainide chain cyclization; C5<-->C13; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2143.46
Aliphatic_Index 61.57895
Aromaticity 0.15789
Average_Rotatable_Bonds 3.52632
Charge_at_pH_7 -0.12356
Isoelectric_Point 6.25670
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 840.19000
X_logP_energy -6.55253
Interaction Information
Affinity KD=0.22 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structure-Function Analysis of a Phage Display-Derived Peptide That Binds to Insulin-like Growth Factor Binding Protein 1
Release_Year 2001
PMID 11456486
DOI 10.1021/bi0103866