PPIRE17405
Target Protein Information
| Protein_Name | Ribonuclease pancreatic |
|---|---|
| Protein_Sequence | MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV |
| Organism_Source | Bos taurus |
| Functional_Classification | ribonucleases |
| Cellular_Localization | Extracellular |
| Gene_Names | RNASE1 |
| UniProt_ID | P61823 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | YNFEVL |
|---|---|
| Peptide_Sequence | YNFEVL |
| Peptide_Length | 6 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 783.88 |
|---|---|
| Aliphatic_Index | 113.33333 |
| Aromaticity | 0.33333 |
| Average_Rotatable_Bonds | 3.83333 |
| Charge_at_pH_7 | -1.00109 |
| Isoelectric_Point | 3.84998 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 10 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 309.44000 |
| X_logP_energy | -0.54440 |
Interaction Information
| Affinity | KD=5.5 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A ribonuclease S-peptide antagonist discovered with a bacteriophage display library |
| Release_Year | 1993 |
| PMID | 8508958 |
| DOI | 10.1016/0378-1119(93)90150-2 |