PPIRE17408
Target Protein Information
| Protein_Name | Chaperone protein DnaK |
|---|---|
| Protein_Sequence | MGKIIGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPFKIIAADNGDAWVEVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKGTGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAEADRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQQQHAQQQTAGADASANNAKDDDVVDAEFEEVKDKK |
| Organism_Source | Escherichia coli O157:H7 |
| Functional_Classification | heat shock proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | dnaK |
| UniProt_ID | P0A6Z0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Oncocin (11) |
|---|---|
| Peptide_Sequence | VDKPPYLPRPR |
| Peptide_Length | 11 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | fluorescein |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1337.59 |
|---|---|
| Aliphatic_Index | 61.81818 |
| Aromaticity | 0.09091 |
| Average_Rotatable_Bonds | 3.27273 |
| Charge_at_pH_7 | 1.99728 |
| Isoelectric_Point | 10.44646 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 526.51000 |
| X_logP_energy | -2.94826 |
Interaction Information
| Affinity | KD=0.55 uM |
|---|---|
| Affinity_Assay | fluorescence resonance energy transfer quenching assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Novel peptiderotein assay for identification of antimicrobial peptides by fluorescence quenching |
| Release_Year | 2012 |
| PMID | 22569846 |
| DOI | 10.1007/s00216-012-6050-3 |