PPIRE17411
Target Protein Information
| Protein_Name | Chaperone protein DnaK |
|---|---|
| Protein_Sequence | MGKIIGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPFKIIAADNGDAWVEVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKGTGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAEADRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQQQHAQQQTAGADASANNAKDDDVVDAEFEEVKDKK |
| Organism_Source | Escherichia coli O157:H7 |
| Functional_Classification | heat shock proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | dnaK |
| UniProt_ID | P0A6Z0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Oncocin 110 |
|---|---|
| Peptide_Sequence | VDKPPYLPRPRPXRXJYNO |
| Peptide_Length | 19 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)O |
| Chemical_Modification | X13=unknown; X15=unknown; J16=tert-leucine; O19=ornithine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | fluorescein |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2152.49 |
|---|---|
| Aliphatic_Index | 56.31579 |
| Aromaticity | 0.10526 |
| Average_Rotatable_Bonds | 3.21053 |
| Charge_at_pH_7 | 2.99642 |
| Isoelectric_Point | 10.64474 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 28 |
| Number_of_Hydrogen_Bond_Donors | 29 |
| Topological_Polar_Surface_Area | 875.74000 |
| X_logP_energy | -7.53639 |
Interaction Information
| Affinity | KD=0.43 uM |
|---|---|
| Affinity_Assay | fluorescence resonance energy transfer quenching assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Novel peptiderotein assay for identification of antimicrobial peptides by fluorescence quenching |
| Release_Year | 2012 |
| PMID | 22569846 |
| DOI | 10.1007/s00216-012-6050-3 |