PPIRE17449
Target Protein Information
| Protein_Name | Solute carrier family 15 member 1 |
|---|---|
| Protein_Sequence | MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPVHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQPNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM |
| Organism_Source | Homo sapiens |
| Functional_Classification | SLC family proton dependent oligopeptide transporter |
| Cellular_Localization | Plasma membrane |
| Gene_Names | SLC15A1 |
| UniProt_ID | P46059 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Lys[Z(NO2)]-Pro |
|---|---|
| Peptide_Sequence | LP |
| Peptide_Length | 2 |
| Peptide_SMILES | CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | K1=4-nitrobenzyloxycarbonyl |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 228.29 |
|---|---|
| Aliphatic_Index | 195.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.00000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 3 |
| Number_of_Hydrogen_Bond_Donors | 2 |
| Topological_Polar_Surface_Area | 83.63000 |
| X_logP_energy | 0.43540 |
Interaction Information
| Affinity | Ki=5.1 uM |
|---|---|
| Affinity_Assay | rapid filtration uptake assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A Novel Inhibitor of the Mammalian Peptide Transporter PEPT1 |
| Release_Year | 2001 |
| PMID | 11284702 |
| DOI | 10.1021/bi0026371 |