PPIRE17453

Target Protein Information
Protein_Name Cytochrome c
Protein_Sequence MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE
Organism_Source Equus caballus
Functional_Classification Cytochromes
Cellular_Localization Mitochondria
Gene_Names CYCS
UniProt_ID P00004
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name K19
Peptide_Sequence KKKKKKKKKKKKKKKKKKK
Peptide_Length 19
Peptide_SMILES NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2453.32
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 5.94737
Charge_at_pH_7 18.99238
Isoelectric_Point 12.05543
Number_of_Hydrogen_Bond_Acceptors 39
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1081.50000
X_logP_energy -7.42430
Interaction Information
Affinity KD=1.5 uM
Affinity_Assay Resonance energy transfer
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Dissociation of Cytochrome c from Liposomes by Histone H1. Comparison with Basic Peptides
Release_Year 1996
PMID 8605203
DOI 10.1021/bi952413w