PPIRE17454
Target Protein Information
| Protein_Name | Cytochrome c |
|---|---|
| Protein_Sequence | MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE |
| Organism_Source | Equus caballus |
| Functional_Classification | Cytochromes |
| Cellular_Localization | Mitochondria |
| Gene_Names | CYCS |
| UniProt_ID | P00004 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Myr-KRTLR |
|---|---|
| Peptide_Sequence | KRTLR |
| Peptide_Length | 5 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Myristoylation |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 672.83 |
|---|---|
| Aliphatic_Index | 78.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.80000 |
| Charge_at_pH_7 | 2.99768 |
| Isoelectric_Point | 12.51648 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 10 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 349.77000 |
| X_logP_energy | -3.58006 |
Interaction Information
| Affinity | KD=2 uM |
|---|---|
| Affinity_Assay | Resonance energy transfer |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Dissociation of Cytochrome c from Liposomes by Histone H1. Comparison with Basic Peptides |
| Release_Year | 1996 |
| PMID | 8605203 |
| DOI | 10.1021/bi952413w |