PPIRE17469

Target Protein Information
Protein_Name Ig gamma-2A chain C region A allele
Protein_Sequence AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK
Organism_Source Mus musculus
Functional_Classification IgG
Cellular_Localization Extracellular
Gene_Names Ighg
UniProt_ID P01863
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 10
Peptide_Sequence CTASARGDLAHLTTTXC
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X16=6-aminohexanoic acid
Cyclization_Method Side chain-side chain cyclization; C1<-->C17; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1677.87
Aliphatic_Index 63.52941
Aromaticity 0.00000
Average_Rotatable_Bonds 3.05882
Charge_at_pH_7 -0.03461
Isoelectric_Point 7.25386
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 757.95000
X_logP_energy -12.35133
Interaction Information
Affinity KD=8.33 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Native-like cyclic peptide models of a viral antigenic site: finding a balance between rigidity and flexibility
Release_Year 2000
PMID 10679891
DOI 10.1002/(SICI)1099-1352(200001/02)13:1<5::AID-JMR480>3.0.CO;2-L