PPIRE17494

Target Protein Information
Protein_Name Microtubule-associated protein 1 light chain 3 beta
Protein_Sequence MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
Organism_Source Homo sapiens
Functional_Classification autophagy adapter
Cellular_Localization Cytoplasm
Gene_Names MAP1LC3B
UniProt_ID Q9GZQ8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FYCO1
Peptide_Sequence DDAVFDIITDEELCQIQEW
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2282.46
Aliphatic_Index 102.63158
Aromaticity 0.10526
Average_Rotatable_Bonds 3.94737
Charge_at_pH_7 -7.05688
Isoelectric_Point 3.07032
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 970.42000
X_logP_energy -6.71350
Interaction Information
Affinity KD=0.29 uM
Affinity_Assay Bio-Layer Interferometry
PDB_ID 5CX3
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Stapled peptide inhibitors of autophagy adapter LC3B
Release_Year 2020
PMID 32406996
DOI 10.1002/cbic.202000212