PPIRE17568

Target Protein Information
Protein_Name High affinity immunoglobulin epsilon receptor subunit alpha
Protein_Sequence MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
Organism_Source Homo sapiens
Functional_Classification Fc receptor
Cellular_Localization Plasma membrane
Gene_Names FCER1A
UniProt_ID P12319
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [Ala7]-MCD
Peptide_Sequence IKCNCKAHVIKPHICRKICGKN
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(C)C
Chemical_Modification None
Cyclization_Method Multi-point cyclization; C3<-->C15; disulfide bond; C5<-->C19; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2507.14
Aliphatic_Index 88.63636
Aromaticity 0.00000
Average_Rotatable_Bonds 3.95455
Charge_at_pH_7 5.93043
Isoelectric_Point 10.24415
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1001.17000
X_logP_energy -9.11313
Interaction Information
Affinity IC50=112 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Partial Alanine Scan of Mast Cell Degranulating Peptide (MCD): Importance of the Histidine- and Arginine Residues
Release_Year 2004
PMID 15214434
DOI 10.1002/psc.532