PPIRE17617

Target Protein Information
Protein_Name Matrix protein
Protein_Sequence MSSLKKILGLKGKGKKSKKLGIAPPPYEEDTSMEYAPSAPIDKSYFGVDEMDTYDPNQLRYEKFFFTVKMTVRSNRPFRTYSDVAAAVSHWDHMYIGMAGKRPFYKILAFLGSSNLKATPAVLADQGQPEYHTHCEGRAYLPHRMGKTPPMLNVPEHFRRPFNIGLYKGTIELTMTIYDDESLEAAPMIWDHFNSSKFSDFREKALMFGLIVEKKASGAWVLDSISHFK
Organism_Source Vesicular stomatitis Indiana virus (strain San Juan)
Functional_Classification Viral matrix proteins matrix protein
Cellular_Localization Nucleus
Gene_Names M
UniProt_ID P03519
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name R39CPNA
Peptide_Sequence RTRQAXRNRRRRWRERQR
Peptide_Length 18
Peptide_SMILES C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification X6=cytosine PNA monomer
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification succinyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2494.82
Aliphatic_Index 5.55556
Aromaticity 0.05556
Average_Rotatable_Bonds 4.94444
Charge_at_pH_7 8.99973
Isoelectric_Point 13.10207
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 55
Topological_Polar_Surface_Area 1379.61000
X_logP_energy -18.70010
Interaction Information
Affinity KD=420 nM
Affinity_Assay fluorescence anisotropy
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Construction of HIV Rev Peptides Containing Peptide Nucleic Acid That Bind HIV RRE IIB RNA
Release_Year 2000
PMID 10714504
DOI 10.1016/S0960-894X(00)00006-8