PPIRE17703

Target Protein Information
Protein_Name Galectin-1
Protein_Sequence MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
Organism_Source Homo sapiens
Functional_Classification lectins
Cellular_Localization Extracellular
Gene_Names LGALS1
UniProt_ID P09382
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name t-PA-peptide-1Lac-C-Fluorescein
Peptide_Sequence GTWSTAESGAECTNWXSSALAQKPYSGRK
Peptide_Length 29
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X16=Ser(u-d-lactose); K29=Fluorescein
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3031.26
Aliphatic_Index 27.24138
Aromaticity 0.10345
Average_Rotatable_Bonds 3.31034
Charge_at_pH_7 0.93812
Isoelectric_Point 8.51864
Number_of_Hydrogen_Bond_Acceptors 47
Number_of_Hydrogen_Bond_Donors 50
Topological_Polar_Surface_Area 1357.70000
X_logP_energy -20.04803
Interaction Information
Affinity KD=0.2 uM
Affinity_Assay Microscale Thermophoresis
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer
Release_Year 2016
PMID 27993133
DOI 10.1186/s12951-016-0236-3