PPIRE17727
Target Protein Information
| Protein_Name | Calcium and integrin-binding protein 1 |
|---|---|
| Protein_Sequence | MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL |
| Organism_Source | Homo sapiens |
| Functional_Classification | EF hand proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | CIB1 |
| UniProt_ID | Q99828 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | UNC10245092 |
|---|---|
| Peptide_Sequence | EDGGSFWYGAMKALYG |
| Peptide_Length | 16 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1751.93 |
|---|---|
| Aliphatic_Index | 36.87500 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 3.37500 |
| Charge_at_pH_7 | -1.00179 |
| Isoelectric_Point | 4.18441 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 24 |
| Number_of_Hydrogen_Bond_Donors | 24 |
| Topological_Polar_Surface_Area | 676.92000 |
| X_logP_energy | -4.64100 |
Interaction Information
| Affinity | KD=29.4 nM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | 6OD0 |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Discovery and Characterization of Peptide Inhibitors for CIB1 |
| Release_Year | 2020 |
| PMID | 32383857 |
| DOI | 10.1021/acschembio.0c00144 |