PPIRE17763

Target Protein Information
Protein_Name CD2 antigen cytoplasmic tail-binding protein 2
Protein_Sequence MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT
Organism_Source Homo sapiens
Functional_Classification GYF domains
Cellular_Localization Nucleus
Gene_Names CD2BP2
UniProt_ID O95400
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 20b
Peptide_Sequence EFGPPPGWLG
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification fluorescein
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1056.19
Aliphatic_Index 39.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 2.50000
Charge_at_pH_7 -1.00024
Isoelectric_Point 3.84998
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 351.94000
X_logP_energy -0.94810
Interaction Information
Affinity KD=27 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 1GYF
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Resin-Bound Aminofluorescein for C-Terminal Labeling of Peptides: High-Affinity Polarization Probes Binding to Polyproline-Specific GYF Domains
Release_Year 2008
PMID 18803191
DOI 10.1002/cbic.200800329