PPIRE17794

Target Protein Information
Protein_Name Bcl-2-like protein 1
Protein_Sequence MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Organism_Source Homo sapiens
Functional_Classification Bcl 2 family
Cellular_Localization Mitochondria
Gene_Names BCL2L1
UniProt_ID Q07817
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Bid i4 9111 (irradiated)
Peptide_Sequence GEQYILSQCGAVLTNKQVDV
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C1<-->C5; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification FAM
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2165.45
Aliphatic_Index 107.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.65000
Charge_at_pH_7 -1.06291
Isoelectric_Point 4.18437
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 949.89000
X_logP_energy -10.60990
Interaction Information
Affinity KD=55 nM
Affinity_Assay Fluorescence Polarization
PDB_ID 1BXL
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Photocontrollable Peptide-Based Switches Target the Anti-Apoptotic Protein Bcl-xL
Release_Year 2008
PMID 19012295
DOI 10.1002/cbic.200800502